Used for stomach ulcers and duodenal ulcers, acute and chronic hyperacid gastritis, esophagitis, and other gastrointestinal diseases, which shows the decrease of acidity and proteolytic activity of gastric juice.
Description
International non-proprietary name or Combination:
Aluminium Oxide + Magnesium Oxide
Dosage form:
Oral suspension
Composition
1 scoop (5 ml) of the suspension contains: Active substance: Algeldrat (aluminum hydroxide gel 2.18 g, corresponding to 218 mg of aluminum oxide), magnesium hydroxide paste is 350 mg, corresponding to 75 mg of magnesium oxide) Excipients: sorbitol 801.150 mg gietelloza 10.900 mg, 10.900 mg of Valium, propilparagidroksibenzoat 1.363 mg, 1.363 mg butilparagidroksibenzoat, sodium saccharinate 0.818 mg, 1.635 mg of lemon oil, ethanol 96% 98.100 mg, purified water to 5 ml.
Description
Suspension of white or off-white in color with a characteristic smell of lemon. When stored at the surface can be allocated a layer of transparent liquid. With vigorous shaking contents of the vial homogeneous suspension is restored.
Pharmacotherapeutic group
Antacid.
Pharmacological action
Pharmacodynamics
Almagel - drug, which is a balanced combination of algeldrata (aluminum hydroxide) and magnesium hydroxide. He neutralizes the free hydrochloric acid in the stomach, reduces the activity of pepsin, which reduces digestive activity of gastric juice. Has a coating, absorbent action. Protects the gastric mucosa by stimulating the synthesis of prostaglandins (cytoprotective effect). This protects the mucosa from inflammatory and erosive lesions gemoragicheskih as a result of irritating and ulcerogenic agents such as ethyl alcohol and non-steroidal anti-inflammatory drugs (eg, indomethacin, diclofenac, aspirin, aspirin, corticosteroids). The therapeutic effect of ingestion occurs within 3-5 minutes. The duration of action depends on the rate of gastric emptying. In the fasting effect lasts up to 60 minutes. When taken within an hour after eating antacid effect can last up to 3 hours. There is no secondary hypersecretion of gastric juice.
Pharmacokinetics
Algeldrat Absorption - resorbed small amounts of the drug, which are practically not alter the concentration of aluminum salts in the blood. Distribution - no. Metabolism - no. Excretion - shows through the intestines. Absorption of magnesium hydroxide, magnesium ions are resorbed in about 10% of the dose and do not alter the concentration of magnesium in the blood. Distribution - usually locally. Metabolism - no. Excretion - shows through the intestines.
Indications for use
Acute gastritis, chronic gastritis with high and normal secretory function of the stomach (exacerbation), acute duodenitis, enteritis, colitis, peptic ulcer and duodenal ulcer (exacerbation), hiatal hernia, gastroesophageal reflux, reflux esophagitis, duodenogastric reflux, symptomatic gastrointestinal ulcers of various origins; erosion of the mucosa of the upper gastrointestinal tract, acute pancreatitis, acute exacerbations of chronic pancreatitis, heartburn and epigastric pain after pogreschnostey in diet, excessive consumption of ethanol, nicotine, coffee, taking drugs that irritate the mucous membrane stomach. Prevention of gastric and duodenal disorders - umenshenie irritant and ulcerogenic effect associated with taking medications that irritate the stomach lining.
Contraindications
Hypersensitivity to the active or to any excipient, a part of the preparation. Severe form of renal failure (because of the risk of hypermagnesemia and aluminum toxicity). Pregnancy. Alzheimer's disease. Hypophosphatemia. Children up to age 10 years. Congenital fructose intolerance (contains sorbitol).
Dosage and administration
Adults and children over 15 years
5 - 10 ml (1-2 scoops) 3-4 times a day. When necessary, a single dose may be increased to 15 ml (3 scoops).
Children from 10 to 15 years
Used in a dose equal to half the adult dose. The drug is taken 45-60 minutes after meals and at night before going to bed. After a therapeutic effect, the daily dose was reduced to 5 ml (1 scoop) 3-4 times a day for 15-20 days. Not recommended fluid intake for 15 minutes after taking Almagel. Each receive a suspension must be thoroughly homogenized by shaking the bottle!
For the prevention of
5-15 ml for 15 minutes before taking the medication from irritating.
Side effect
Almagel can cause constipation, which takes place after dose reduction. In rare cases, nausea, vomiting, stomach cramps, changes in taste, allergic reactions and gipermagniemiya (increase of magnesium in the blood). With prolonged use of the drug in patients with renal insufficiency and dialysis may change the mood and mental activity. During chronic administration of high doses of the drug along with the lack of phosphorus in the diet, may cause osteomalacia.
Overdose
When a single dose is not exceeded, there are other signs of overdose than constipation, bloating, feeling metallic taste in the mouth. With prolonged use of high doses of possible kidney stones, the emergence of severe constipation, mild drowsiness, gipermagniemiya. There may be also signs of metabolic alkalosis: a change of mood or mental activity, numbness or pain in the muscles, nerves, and fatigue, slow breathing, unpleasant taste. In these cases, you must immediately take measures for the rapid removal of the drug from the body - gastric lavage, induce vomiting, activated charcoal.
Interaction with other drugs
Can absorb certain medications, thus reducing their absorption, so while taking other medicines, their nebhodimo take 1-2 hours before or after taking Almagel. Almagel reduces gastric acidity, and this can affect the action of many medications at the same time taking. Almagel reduces the effect of H2 blockers gistamiovyh receptor (cimetidine, ranitidine, famotidine), cardiac glycosides, iron salts, lithium, quinidine, Valium, phenothiazine drugs, antibiotics tetracycline, ciprofloxacin, isoniazid and ketoconazole. Concomitant administration of enteric preparations increased gastric pH can lead to accelerated infringement of their shell and cause irritation of the stomach and duodenum. Almagel can affect the results of some laboratory and functional studies and tests: it reduces the gastric secretion, and so alters the results of functional studies of its acidity, alters the results of tests using technetium (Ts99), such as bone scintigraphy and some tests for the study of the esophagus, increased serum phosphorus, pH values of serum and urine.
Cautions
It is not recommended to use the drug in patients with severe constipation, with stomach pain of unknown origin with suspected acute appendicitis, in the presence of ulcerative colitis, diverticulosis, colostomy or ileostomy, with chronic diarrhea, acute hemorrhoids, when the acid-base balance in the body and also in the presence of metabolic alkalosis, liver cirrhosis, severe heart failure, with toxicosis of pregnant women, with renal impairment (creatinine clearance <30 ml / min, due to the risk of hypermagnesemia and aluminum toxicity). In long-term treatment (more than 20 days) requires regular medical monitoring of serum magnesium levels in patients with renal insufficiency. The product contains no sugar, so you can make him sick with diabetes. The product contains sorbitol, which is contraindicated in congenital fructose intolerance.
Use during pregnancy and lactation
Studies in animals have shown no evidence of a teratogenic potential or other adverse effects on the embryo and / or fetus. No clinical data are available almagel pregnant women. The drug is not recommended during pregnancy, but if the intended benefits of its use outweighs the potential risk to the fetus, the drug should be taken under medical supervision is not more than 5-6 days. No data on the release of the active drug substance in breast milk. Almagel can be used in breast-feeding only after careful evaluation of the benefit to the mother and the potential risk to the newborn. During breast-feeding, do not use more than 5-6 days under medical supervision.
Impact on the ability to drive a car and operate machinery
Almagel no effect on the ability to drive and use machines. When taken at the recommended daily dose contained in the product alcohol has no effect on the ability to drive a car and operate machinery.
Form release
Oral suspension.
To 170 ml of the product in a dark glass bottle with screw plastic cap. Each vial along with instructions for use and the measuring spoon to 5 ml in a carton box.
To 170 ml of the product in the vial of polyethylene plastic with a screw cap. Each vial along with instructions for use and the measuring spoon to 5 ml in a carton box.
Storage conditions
In the dark place at a temperature not exceeding 25 ° C. Do not freeze! Keep out of reach of children!
Shelf life
2 (two) years. Do not use after the expiration date printed on the package!
Pharmacy purchasing terms
Without a prescription.
It is believed that symptomatic hemorrhoids affect at least 50% of the US population at some time during their lives, and around ~5% of the population is affected at any given time. Both sexes experience approximately the same incidence of the condition, with rates peaking between 45 and 65 years. They are more common in Caucasians and those of higher socioeconomic status.
ReplyDeleteLong-term outcomes are generally good, though some people may have recurrent symptomatic episodes. Only a small proportion of persons end up needing surgery.